Dirección

• Elaine Schreyeck — script supervisor
• Ray Kellogg — second unit director
• Andrew Marton — second unit director
• Joseph L. Mankiewicz — director
• Fred R. Simpson — assistant director

Producción

• Stuart Lyons — casting consultant
• Walter Wanger — producer
• Peter Levathes — executive producer
• C.O. Erickson — production manager
• Forrest E. Johnston — production manager

Sonido

• Bernard Freericks — sound recordist
• Murray Spivack — sound recordist
• Alex North — original music composer

Montaje

• Dorothy Spencer — editor

Guion

• Joseph L. Mankiewicz — screenplay
• Ranald MacDougall — screenplay
• Sidney Buchman — screenplay
• Carlo Maria Franzero — book
• Plutarch — original story
• Suétone — original story
• Appian — original story

Reparto

• Elizabeth Taylor — Cleopatra
• Richard Burton — Marcus Antonius
• Rex Harrison — Julius Caesar
• Pamela Brown — High Priestess
• George Cole — Flavius
• Hume Cronyn — Sosigenes
• Cesare Danova — Apollodorus
• Kenneth Haigh — Brutus
• Andrew Keir — Agrippa
• Martin Landau — Rufio
• Roddy McDowall — Octavian - Caesar Augustus
• Robert Stephens — Germanicus
• Francesca Annis — Eiras
• Grégoire Aslan — Pothinus
• Martin Benson — Ramos
• John Doucette — Achillas
• Michael Hordern — Cicero
• John Hoyt — Cassius
• Carroll O'Connor — Casca
• Andrew Faulds — Canidius
• Michael Gwynn — Cimber
• Peter Grant — Palace Guard (uncredited)
• Marne Maitland — Euphranor
• Richard O'Sullivan — Pharaoh Ptolemy XIII
• Gwen Watford — Calpurnia
• Douglas Wilmer — Decimus
• Marie Devereux — Bacchanal Reveler
• Herbert Berghof — Theodotos
• Jacqueline Chan — Lotos
• Isabel Cooley — Charmian
• Mike Steen — Minor Role
• Finlay Currie — Titus (uncredited)
• Meri Welles — Cleopatra's Handmaiden
• Peter Forster — Officer
• John Alderson — Roman Officer (uncredited)
• John Alderton — 1st Officer (uncredited)
• Jeremy Kemp — Agitator (uncredited)
• Desmond Llewelyn — Senator (uncredited)
• Jean Marsh — Octavia (uncredited)
• Laurence Naismith — Arachesilaus (uncredited)
• Larry Taylor — Roman Officer (uncredited)
• Ben Wright — Narrator (voice) (uncredited)

Cámara

• Leon Shamroy — director of photography
• Franco Di Giacomo — camera operator
• Gerry Fisher — camera operator
• Bob Penn — still photographer
• Larry Shaw — still photographer

Arte

• Herman A. Blumenthal — art direction
• Hilyard M. Brown — art direction
• Boris Juraga — art direction
• Maurice Pelling — art direction
• Jack Martin Smith — art direction
• Elven Webb — art direction
• Paul S. Fox — set decoration
• Ray Moyer — set decoration
• Walter M. Scott — set decoration
• Giovanni Natalucci — set designer
• John DeCuir — production design
• Don Picton — assistant art director

Vestuario y maquillaje

• Vittorio Nino Novarese — costume design
• Renié — costume design
• Alberto De Rossi — makeup artist
• Vivienne Walker — hairstylist
• Irene Sharaff — costume design

Equipo técnico

• Ferdinand Bellan — scenic artist
• Hermes Pan — choreographer
• Ray Austin — stunt coordinator